Moreover, intracellular oxidative stress and mitochondrial dysfunction seem to be upstream events that mediate hypothalamic NFκB activation under overnutrition, and in turn such metabolic inflammation is reciprocally related to the induction of various intracellular stresses such as mitochondrial oxidative stress and endoplasmic reticulum (ER) stress [62]. This evidence concerns the gene NFKB1 and overnutrition.