NLRP3 and pancreatitis: Here we found that, although HRS failed to suppress plasma pancreatic enzymes activity, it significantly attenuated the pancreatic damage in mice in response to the induction of pancreatitis, together with the impaired NLRP3 inflammasome activity, suggesting that the potential of HRS to block the NLRP3 inflammasome activation was probably involved in the amelioration of pancreatic injury.