Patients with CNV/AMD have autoantibodies to various antigens such as alpha beta crystallin, alpha-actinin, amyloid, C1q, chondroitin, collagen I, collagen III, collagen IV, elastin, fibronectin, heparan sulfate, histone H2A, histone H2B, hyaluronic acid, laminin, proteoglycan, vimentin, and vitronectin systemically expressed [96]. This evidence concerns the gene VIM and age-related macular degeneration.