Our data showed that the enhanced expressions of TLR4 by LPS challenge were significantly downregulated with pretreatments of CFE at the doses of 80 and 120 mg/kg, which corresponded with the level changes of IκBα, NF-κB p65, and other proinflammatory cytokines, in ALI mice lung tissues. Here, NFKB1 is linked to acute respiratory distress syndrome.