This study aimed at bridging important gaps in IL-6 research in schizophrenia patients, including the association between the IL6 -174G/C polymorphism and serum IL-6 level, the influence of IL-6 level alterations on clinical and psychopathological manifestation, as well as the relationship between IL-6 production and cognitive functioning among patients with schizophrenia. Here, IL6 is linked to schizophrenia.