The observation were further supported by statistical analysis which showed significant difference of Crm1 between nuc and >ch500 (Fig. 5B, b), and significant difference of NS2 between ch150 and ch500 (Fig. 5b c) in WD but not WD–NS2(L19S) infection, confirming the role of NS2–CHD3 interaction in locating NS2 and Crm1 on dense chromation. The gene discussed is XPO1; the disease is infection.