To confirm this, COS-1 cells were fractionated into cytoplasmic (cyt), nucleoplasmic (nuc), low-salt chromatin (ch150), high-salt chromatin (ch500), and very high-salt chromatin (>ch500) fractions (Fig. 4a) under infection for analyzing the distribution of CHD3, Crm1, NS2, and NP. The gene discussed is XPO1; the disease is infection.