BRAF and neoplasm: Regorafenib is an orally administered multikinase inhibitor that blocks the activity of a number of protein kinases associated with angiogenesis (VEGF receptors 1–3 and TIE2), oncogenesis (KIT, RET, RAF1, BRAF, and BRAF V600E) and the tumor microenvironment (platelet-derived growth factor receptor and fibroblast growth factor receptor) [6].