In light of this and the fact that we have previously shown ERK2 to be recruited to chromatin by ERα after estradiol treatment of breast cancer cells [45], we assessed the recruitment of ERK2 to chromatin after 4-OH-TAM exposure of cells and the extent of overlap of ERK2 binding with FOXM1 and ERα binding (Figure 2E). Here, ESR1 is linked to breast carcinoma.