Our genome-wide analyses using chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) revealed that TAM-specific FOXM1 binding sites are associated with genes encoding markers of CSCs and invasiveness and that overexpression of FOXM1 increases the proportion of CSCs and directly regulates the production of factors that promote aggressiveness and therapy resistance in breast cancer. This evidence concerns the gene FOXM1 and breast cancer.