TG and neoplasm: The following predictive factors of malignancy have been reported in the literature [5, 13, 14, 17–41]: the patient’s age [18, 19, 24, 25, 30–33] and sex [5, 26], the tumor size [5, 18, 20–22, 24–26, 31–36, 42], a solitary nodule [24, 26, 27], tumor fixation [25], a lesion that feels hard on palpation [27], Tg concentration [13, 14, 18], ultrasound characteristics [17, 27–29, 41], cytologic characteristic [21], and gene expression diagnostic markers [37–40].