AKT1 and breast cancer: Importantly, we also found that this PTEN-low gene signature is significantly correlated with several known oncogenic gene signatures from human breast cancer with complete PTEN loss [32], AKT transgenic mouse [29], or epidermal growth factor receptor (EGFR)- or ERBB2-transfected MCF7 cells (Figure 1F, P <0.05, Pearson’s correlations), and is closely correlated with gene signature from constitutively active MEK-transfected MCF7 cells (P = 0.07) [30].