To confirm whether EFEMP1 expression was regulated by promoter methylation and/or histone PTMs, three PCa cell lines (LNCaP, PC-3, VCaP) were treated with 1 μM DAC for 72 hrs, 0.5 μM TSA for 24 hrs or both in combination. This evidence concerns the gene EFEMP1 and posterior cortical atrophy.