EFEMP1 and posterior cortical atrophy: Significantly lower transcript levels of EFEMP1 were found in PCa tissues compared with NPT (P < 0.001, Mann–Whitney U-test) and those inversely correlated with promoter methylation levels (r = −0.403; P < 0.001) (Fig. 3), suggesting an association between EFEMP1 promoter methylation and gene silencing in PCa.