Herein, we sought to validate EFEMP1 promoter methylation as a potential PCa biomarker as well as to explore the role of DNA methylation and histone PTMs in EFEMP1 down-regulation (transcript and respective protein – Fibulin-3 – levels) and its impact in on PCa tumourigenesis, thus uncovering the biological relevance of EFEMP1 epigenetic deregulation. The gene discussed is EFEMP1; the disease is posterior cortical atrophy.