As shown in Figure 5A, IL-10 neutralization resulted in significantly increased frequencies of monofunctional (IL-2 or INF-γ or TNF-α expressing) and multifunctional (IL-2/IFN-γ or IFN-γ/TNF-α or IL-2/TNF-α co-expressing) Th1 cells in FIL/TB individuals. This evidence concerns the gene IL10 and tuberculosis.