On the other hand, IL-10 neutralization resulted in significantly increased frequencies of monofunctional (IL-2 or INF-γ or TNF-α expressing) but not multifunctional (IL-2/IFN-γ or IFN-γ/TNF-α or IL-2/TNF-α co-expressing) Th1 cells in TB alone infected individuals (Figure 5C). The gene discussed is IFNG; the disease is tuberculosis.