D.A. Omahen, noting increased expression of both COX-2 and 5-LO in gliomas, suggested in 2011 treating gliomas with simultaneous COX and 5-LO inhibitors  ̈using readily available, well-tolerated medications ̈,  ̈thereby priming glioma cells for treatment-induced apoptotic cell death ̈ [195]. Here, ALOX5 is linked to central nervous system cancer.