APC and adenocarcinoma: In this study, we provide evidence that loss of Apc significantly increases the number of Dclk1+ cells in the small intestine and particularly in dysplastic and adenocarcinoma regions of advanced polyps, supporting the previous hypotheses that (i) stem like cells or stem cells are more abundant in cancerous conditions and (ii) the loss of function of Apc increases the expansion of the TSC compartment [3, 24].