To verify that the Dclk1 upregulation in tumors of Apc mutation with activated wnt, we did IHC for β-catenin and found that β-catenin was localized in the intestinal regions identified as high-grade dysplasia and adenocarcinoma, and most of them strongly stained in the nucleus (Supplementary Figure 3A). The gene discussed is APC; the disease is adenocarcinoma.