Moreover, both ligand (LT-β) and receptor (LTβR) have been shown expressed in non-Hodgkin's lymphoma cells including MCL [26], which potentially leads to constitutive activation of NF-kB signaling [27], suggesting a pathogenic role of the LT-β/LTβR axis in lymphomagenesis [28-30]. This evidence concerns the gene NFKB1 and mantle cell lymphoma.