Recent laboratory studies have indicated that an abnormal phase angle between the circadian clock and the sleep-wake cycle (approximately 4.0–6.0 h) can have adverse effects on metabolism (e.g., glucose, insulin, triglyceride, and leptin) [46]–[48] and might cause health problems such as cardiovascular disease and metabolic disorders [7], [48]. The gene discussed is INS; the disease is metabolic disease.