Using shRNA, we knocked down endogenous Snail in Rpb3-overexpressing QGY-7701 cells and HepG2 cells (Supplemental Figure S6A) and found (using the MTT assay) that knockdown of Snail inhibited HCC cell proliferation in vitro (Supplemental Figure S6B and C). This evidence concerns the gene SNAI1 and hepatocellular carcinoma.