The mice inoculated subcutaneously with HCC-LM3/Rpb3 shRNA1 cells, HCC-LM3/Rpb3 shRNA2 cells and SMMC-7721/Rpb3 shRNA1 cells, SMMC7721/Rpb3 shRNA2 cells, exhibited dramatically reduced tumor volumes compared with mice receiving HCC-LM3/Ctrl shRNA and SMMC-7721/Ctrl shRNA cells (Fig. 2J). Here, POLR2C is linked to hepatocellular carcinoma.