PIK3CA and Miyoshi myopathy: In addition to the aforementioned genes, the PI3K/Akt/mTOR, Ras/MAPK,Bcl, Hippo, and Wnt pathways and their components are the most altered pathways in MM.Several studies have focused on the modulation of these pathways for a safe andeffective reduction in the malignant growth of MM, including in vitro studies, animalstudies, and clinical trials.