Phosphorylated Akt is responsible for sendingbiochemical signals responsible for cell proliferation and resistance toapoptosis.(64) The PIK3CA gene encodes the catalytic unit p110α, whichis known for its ability to activate the PI3K pathway by converting PIP2 toPIP3.(81) It is known that Akt is phosphorylated by mammalian target of rapamycin(mTOR), and the mTOR complex plays an important role in energy balance and growth,being therefore a therapeutic target of interest in patients with MM.(82). This evidence concerns the gene MTOR and Miyoshi myopathy.