TP53 and Miyoshi myopathy: Thefirst clues as to the role of p53 in mediating apoptosis were provided by a studypublished in the 1990s.(48) A new mechanism of action of p53 has recently been identified and isbelieved to be one of the main mechanisms used to fight the process of malignanttransformation, i.e., induced cellular senescence.(49) However, the role of the p53 protein in MM has yet to be well defined;intriguingly, in most cases, MM does not neutralize p53 activity in a direct manner,i.e., through TP53 mutations.