Individuals MD-6 and MD-7 (carrying a SUN2 variant in addition to LMNA T528K and R99P mutations, respectively) also had more severe disease than is typical for EDMD, with early onset at age 1 and 4 years, respectively, and unusually early requirement for heart transplantation. This evidence concerns the gene FBXW2 and Emery-Dreifuss muscular dystrophy.