The study of protein expression and distribution of PPAR-γ and CIDEC in VAT showed low expression during the late phase in HFD induced obesity and over expression in mice given high fat diet and treated with pioglitazone, which validates that VAT is responsible for the insulin resistance during the late phase of obesity, and preventing decrease in CIDEC during late phase of obesity plays an important role in controlling blood sugar levels [30]. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.