PPARG and obesity due to melanocortin 4 receptor deficiency: Interestingly, the mRNA expression of CIDEC and PPAR-γ in subcutaneous adipose tissue (SAT) increased gradually in HFD group and during the late phase of obesity this increased expression of both the genes maintained a high level and showed no significant decrease, except PPAR-γ which showed significant decrease in expression after 16 weeks of obesity.