The molecular mechanism underlying FOXM1 overexpression in various cancers is not well understood.21 We show that MEIS2 is essential for maintaining the expression of FOXM1 in neuroblastoma cells and FOXM1 is a direct target gene of MEIS2, suggesting that high-level expression of MEIS2 is a major mechanism underlying FOXM1 overexpression in neuroblastoma. The gene discussed is FOXM1; the disease is neuroblastoma.