FOXM1 and neoplasm: In addition, it has been reported recently that FOXM1 is overexpressed in primary neuroblastoma tumors and is essential for the tumorigenicity of neuroblastoma cells.38 Consistent with the report, we found that high FOXM1 expression is significantly associated with poor prognosis and advanced tumor stages in neuroblastoma patients (Supplementary Figures S6c and d).