It is known that cells with FOXM1 depletion display mitotic spindle defects, centrosome amplification, chromosome mis-segregation, failure of cytokinesis, and mitotic catastrophe,35, 36, 37 which are essentially the same phenotypes displayed by neuroblastoma cells with MEIS2 depletion as described above. The gene discussed is FOXM1; the disease is neuroblastoma.