FOXM1 was originally identified as a transcription factor that activates the expression of many mitotic genes and is essential for execution of the mitotic program.35, 36, 37 High FOXM1 expression is a common feature of many types of cancers and is associated with poor prognosis.20, 21 FOXM1 is also overexpressed in primary neuroblastoma tumors and is essential for the tumorigenicity of neuroblastoma cells.38 Our study reveals that higher FOXM1 expression is significantly associated with advanced stages of neuroblastoma and decreased survival of neuroblastoma patients. The gene discussed is FOXM1; the disease is cancer.