HLA-DOB and systemic lupus erythematosus: The results showed that the expressions of genes related to SLE (HLA-DQA2, HLA-DOB and HIST1H2BD) were dramatically downregulated (Figure 2b), whereas the expressions of genes related to cell cycle (CCNA2, CDC2, CDKN2C, CCNE2, E2F7 and PCNA) were significantly upregulated, except for CDC42 (Figure 2c).