SLE is associated with the dysregulation of B cells,43 mainly characterized by abnormal homeostasis and hyperactivation.8, 9 In this study, we first showed an increased mortality of CD19+CD27− and CD19+IgM+ B-cell subsets from active SLE patients and a differential expression profile correlated to signaling pathways including IFN, TLR and BCR as well as the apoptosis, necroptosis and immune pathways. This evidence concerns the gene CD40LG and systemic lupus erythematosus.