In fact, spleen tissue of all mice and liver and MLN tissue of the majority of neonates (8/14 and 18/23, respectively) remained sterile at day 2 and 4 after infection by SPI1 deficient Salmonella. Similarly, systemic dissemination of ΔinvC Salmonella was also highly significantly reduced after high dose (105 CFU) infection (Fig. S2D). The gene discussed is SPI1; the disease is infection.