POMC and Cushing syndrome: We found in a previous study [14] that the NFAI patients have higher cortisol and 17-OHP responses to ACTH as healthy subjects have, but patients with subclinical Cushing’s syndrome are not excluded from this NFAI study population, and the ACTH-induced cortisol and 17-OHP levels are actually higher in the previous study than those in the current one.