On a Brazilian population including 169 patients with cardiomyopathy and 76 asymptomatic individuals, the frequency of homozygosity for the MAL/TIRAP 180S allele was significantly higher among patients with CCC than among asymptomatic patients, whereas the percentage of subjects homozygous for the MAL/TIRAP 180L allele was similar in both groups. Here, TIRAP is linked to cardiomyopathy.