Taken together, our results may suggest that genetic polymorphisms affecting local expression of CXCL9 and possibly CXCL10 control the intensity of myocarditis through modulation of CXCL9 and/or CXCL10 expression in the myocardium and the ensuing effects on the local expression of chemokine ligands of the CXCR3/CCR5/CCR4/CCR7. The gene discussed is CXCL10; the disease is myocarditis.