MYC and gastric carcinoma: Intestinal type gastric carcinoma is associated with high expression of c-myc through NF-κB/p65 activated by H. Pylori cagA [54] H. pylori cagA mediates mitogenic signal through Src homology 2 (SH2) domain-containing protein-tyrosine phosphatase-2 (SHP-2) activation in the infected cells [55].