Epidermal growth factor receptor is an important gene related to the proliferation of keratinocytes in psoriasis, and it has been validated to be a target gene of miR-146a 23.To evaluate whether the rs2910164G>C change in miR-146a affects its post-transcriptionally regulatory effect on EGFR expression, the miR-146a expression plasmids (rs2910164G or C allele) were transfected into HaCaT cells and normal human keratinocytes. The gene discussed is EGFR; the disease is psoriasis.