Also, in cells expressing the I3C-resistant elastase, treatment with I3C failed to stimulate the MDM2–nucleostemin or inhibit the MDM2–p53 bimolecular interactions, and prevented I3C from triggering its apoptotic response in cell cultures or to inhibit growth of 10AT-Her2 cell-derived tumor xenografts. The gene discussed is TP53; the disease is neoplasm.