The functional role of elastase in mediating the in vivo effects of I3C on tumor xenograft growth was determined by implanting NIH III athymic mice with 300,000 10AT-Her2 cells stably transfected with either the WT or I3C-resistant ∆205 forms of elastase as well as cells transfected with the EV. The gene discussed is ERBB2; the disease is neoplasm.