Initial evidence for a possible role of LPA and its receptors in EMT was derived from experiments in hepatocellular carcinoma and ovarian cancer by showing a proline-rich tyrosine kinase 2 (PYK2) or periostin (alias osteoblast-specific factor-2)-induced EMT, upon LPA treatment [33, 34]. This evidence concerns the gene PTK2B and ovarian carcinoma.