Since the association of the ERCC2 Lys751Gln (rs13181) polymorphism with ESCC risk was first reported in 20025, there are additional investigations of the association between Lys751Gln and risk of ESCC among different ethnicities6, 7, 8, but the results have been mixed or conflicting, likely due to a relatively small sample size in each of the published studies. This evidence concerns the gene ERCC2 and esophageal squamous cell carcinoma.