HK1 and breast cancer: The activities of hexokinase (HK), aldolase (ALD), pyruvate kinase (PK) and lactate dehydrogenase (LDH) are 3 to 7 times higher in human breast cancer than in normal tissue [11]-[13], although it is unclear if TNBC cells are particularly more active in glycolysis and more dependent on this pathway for ATP generation compared to other breast cancer cells.