The activities of hexokinase (HK), aldolase (ALD), pyruvate kinase (PK) and lactate dehydrogenase (LDH) are 3 to 7 times higher in human breast cancer than in normal tissue [11]-[13], although it is unclear if TNBC cells are particularly more active in glycolysis and more dependent on this pathway for ATP generation compared to other breast cancer cells. Here, HK1 is linked to breast carcinoma.