IHC analyses for IL-4R subunits in TMA with 60 samples revealed that a significant number of tumor samples with advanced epithelial BC grade 2 and 3 disease showed an intense immunostaining for IL-4Rα compared to grade 1 disease, while IL-13Rα1 expression was marginal and not different between grades of the disease. This evidence concerns the gene IL4R and neoplasm.