Tepper et al., have shown that T cells, B cells, NK cells, and mast cells are not required for the IL-4 induced protective immunity, because no tumor have grown in nu/nu (deficient of T cells), SCID (deficient of T and B cells), bg/bg (deficient of NK cells), w/wv (deficient of mast cells) mice that received s.c. Here, IL4 is linked to neoplasm.