TPPP and multiple system atrophy: Immunohistochemistry for TPPP in the pons of control individuals (Figure 4a-c) and MSA patients (Figure 4d-g) showed that TPPP is diminished in MSA in the neuropil (Figure 4f) and accumulated in the perinuclear cytoplasm of oligodendroglia (Figure 4f and g), corresponding to the relocalization of TPPP from the myelin sheath to the cytoplasm, as previously described [8,12].