We found that nuclear TPPP was significantly reduced in the MSA-oligodendroglia that did not possess obvious GCIs (i.e., type 1 & 2 oligodendroglia) (type 1/types 1 + 2 in MSA = 48.63 ± 10.37% vs type 1/types 1 + 2 in controls = 62.4 ± 13.5%, p = 0.0185) (Figure 4k). Here, TPPP is linked to multiple system atrophy.