In addition, the prevalence of nuclear TPPP was further reduced among the MSA-oligodendroglia with pα-syn immunoreactivity (i.e., GCI-positive oligodendroglia) (types 3 + 5/types vs 3 + 4 + 5 + 6 in MSA = 19.6 ± 10.9%, p < 0.001). The gene discussed is TPPP; the disease is multiple system atrophy.