Among the oligodendroglia with GCIs (types 3–6), the prevalence of nuclear TPPP was almost negligible in those without cytoplasmic TPPP (types 5 and 6; type5/types 5 + 6 in MSA = 0.69 ± 1.47%), demonstrating that type 5 (exclusively nuclear TPPP with a GCI) oligodendroglia are very rare. Here, TPPP is linked to multiple system atrophy.