IRF4 and lymphoma: Of note, CFLAR is also downregulated by shIRF4 in JiJoye cells (1.32 fold) in the microarray results, consistent with the results from GEO bioinformatics that IRF4 correlates with CFLAR in non-Hodgkin’s lymphomas and depletion of IRF4 downregulated CFLAR protein level in EBV+ lymphoma cells (Fig. 4).