For example, in vitro studies have found that lupenone stimulates melanogenesis in B16 murine melanoma cells [10], as well as inhibits α-glucosidase (α-Glu) and protein tyrosine phosphatase 1B (PTP1B) activities [11,12], Furthermore, lupenone inhibits adipogenic differentiation via downregulation of peroxisome proliferator-activated receptor PPARγ expression in 3T3-L1 cells [13]. The gene discussed is PTPN1; the disease is melanoma.