In addition, Kaplan-Meier analysis demonstrated that HSP60 overexpression (P = 0.002), larger tumor size (P<0.001), tumor site (P = 0.008), prominent serosal invasion (P<0.001) and lymph node metastasis (P<0.001) were negative prognostic factors for RFS in gastric cancer patients (Table 2). This evidence concerns the gene HSPD1 and gastric cancer.