However, Cappello et al. [23] compared the HSP60 and HSP10 expression in lung cancer with that of chronic obstructive pulmonary disease by immunohistochemistry and found the contradictory results that the loss of HSP60 and HSP10 immunopositivity is related to the development and progression of bronchial cancer in smokers with chronic obstructive pulmonary disease. This evidence concerns the gene HSPD1 and chronic obstructive pulmonary disease.