miR-195 targets mouse protein-25 (MO25), a central component of the MO25/Ste20 Related Adaptor (STRAD)/liver kinase B1 (LKB1) complex that acts as an upstream kinase for adenosine monophosphate-activated kinase (AMPK), a prominent player in the development of cardiac hypertrophy and heart failure [63]. The gene discussed is CAB39; the disease is heart failure.