Although there is no evidence of causative correlation between kidney disease and glaucoma, several genetic disorders such as nail-patella syndrome (LMX1B), oculocerebrorenal syndrome (OCRL) and mutations in the type IV collagen gene (COL4A1), are associated with both development of nephropathy and developmental glaucoma [47], [48], [49], [50]. The gene discussed is COL4A1; the disease is hereditary disease.