For instance hyper- DNA methylation of RELN, SOX10 [SRY (sex determining region Y)-box 10], FOXP2 (forkhead box P2), and HTR2A as well as hypo- DNA methylation of MB-COMT (membrane-bound catechol-O-methyltransferase) and HTR2A have been reported in schizophrenia (Grayson et al., 2005; Iwamoto et al., 2005; Abdolmaleky et al., 2006, 2011; Tolosa et al., 2010). Here, COMT is linked to schizophrenia.