APOBEC3H and infection: A3H Hap II prefers to deaminate ssDNA at 5′TC sites, similar to A3F and A3D, and appears have a high mutagenic potential and ability to restrict HIV in both single-cycle and spreading infection experiments and in HIV-infected individuals (Harari et al., 2009; Hultquist et al., 2011; Wang et al., 2011a; Ooms et al., 2013a).