HK2 and neoplasm: HK1 has been reported to dissociate from isolated heart mitochondria when G‐6‐P or ATP are added, an effect prevented or reversed by the presence of Mg2+ or phosphate (Aubert‐Foucher et al., 1984) and G‐6‐P has also been shown to cause HK2 dissociation from tumour cell mitochondria (Pastorino et al., 2002).