VEGFA and neoplasm: The process of tumor vascularization is essential to allow solid tumors to grow beyond a minimal size and it has been suggested that the ability of a tumor cell to produce and secrete VEGF is crucial and involves several steps: 1) The liberation of pro-angiogenic factors from tumor cells, including VEGF; 2) Changes in the morphology of endotheliocytes; 3) Liberation of proteolytic enzymes that degrade the basal lamina; 4) Migration and formation of tubular structures; 5) Proliferation of endotheliocytes and 6) Differentiation into capillaries[2].