When Wnts bind to their receptors, the aforementioned multi-protein complex is disassembled, β-catenin is no longer phosphorylated or degraded, cytoplasmic levels increase and the protein translocates to the nucleus where, together with Tcf/Lef family members, transcription of many genes implicated in development and progression of cancer are increased, including survivin, COX-2, Cyclin D1, Runx-2 and VEGF[26]–[30]. The gene discussed is HNF4A; the disease is cancer.