Interestingly, TBL1XR1 is thought to regulate the expression of nuclear hormone receptor co-repressors38, and both tissue types in which TBL1XR1–PIK3CA fusions were found (invasive breast carcinoma and prostate cancer), are hormone driven and ranked among the highest for TBL1XR1 mRNA expression across all normal tissues (Supplementary Fig. 12). Here, PIK3CA is linked to Familial prostate cancer.