On the other hand, some cytokines are negative regulators of eosinophil differentiation; for example, IL-12 selectively inhibits eosinophilopoiesis from bone marrow stem cells through IFNγ induction [29, 30], reinforcing the importance of the T-helper type 1 versus T-helper type 2 balance in allergic asthma. The gene discussed is IFNG; the disease is allergic asthma.