In conclusion, we demonstrated that wogonin could inhibit the invasion and metastasis of B16-F10 melanoma cells in vitro and in vivo. By studying the molecular mechanisms of wogonin against B16-F10 melanoma cells, we have confirmed that wogonin inhibited Ras expression, as well as ERK, AKT and NF-κB pathways, which are the possible upstream targets of MMP-2. Here, NFKB1 is linked to melanoma.