Very recently, it has been shown that self miRNAs also interact with receptors of innate immunity, namely TLR-7: in this way, miR-let-7b from cerebrospinal fluids exacerbates neurodegeneration in Alzheimer’s disease [4] and tumour-secreted miR-21 and miR-29a promote prometastatic and inflammatory responses [5]. Here, TLR7 is linked to early-onset autosomal dominant Alzheimer disease.