MDM4 and neoplasm: We expected that there should be a gene-gene interaction between MDM4 rs4245739 and TP53 Arg72Pro genetic variants since the functional TP53 codon 72 Arg>Pro change could depress the activities of TP53 in inducing apoptosis and suppressing transformation [24], [25] and MDM4 can negatively regulate TP53 tumor suppression function [16], [17].