However, compared with the MDM4 AA genotype, a significantly decreased risk of NHL was associated with the MDM4 AC and CC genotypes only among males (OR = 0.21, 95% CI = 0.08–0.54, P = 0.001), but not among females (OR = 1.35, 95% CI = 0.52–3.47, P = 0.536). This evidence concerns the gene MDM4 and non-Hodgkin lymphoma.