In ovarian cancer, retinoblastoma and esophageal cancer cells, miR-191 could selectively bind to the MDM4-C allele mRNA but not the MDM4-A allele mRNA, which resulting in a statistically significant increased expression of MDM4 mRNA and protein among the MDM4 rs4245739 A allele carriers [20]–[22]. This evidence concerns the gene MDM4 and esophageal cancer.