CDKN2A and non-small cell lung carcinoma: Brock et al. [48] also confirmed that methylation of the promoter region of the cyclin-dependent kinase inhibitor 2A gene p16, the H-cadherin gene CDH13, the Ras association domain family 1 gene RASSF1A, and the adenomatous polyposis coli gene APC in patients with stage I NSCLC treated with curative intent by means of surgery is associated with early recurrence.