To assess the effect of Ad5hr infection on pDC (CD3−, CD14−, CD16−, CD19−, CD20−, CD56−, HLA-DR++, and CD123+) frequency and function, the absolute number of pDC in blood and the ability of blood pDC to produce IFN-alpha in response to in-vitro stimulation with herpes simplex virus were determined [33], [34]. Here, CD14 is linked to infection.