ESR1 and breast carcinoma: Study-specific proportions of ER+ disease tended to increase with increasing average (mean/median) age at breast cancer diagnosis in both North and sub-Saharan Africa (e.g., pooled ER+ prop [95% CI] for sub-Saharan studies with an average age at diagnosis of 31–46, 47–49.4, and 49.5+ years were 0.34 [0.24–0.44], 0.45 [0.28–0.62], and 0.49 [0.35–0.64]; I2>90%, p<0.01 for all).